歐洲專利：一種吻/閉合口加固修復組合件及其制備和使用方法

作者：本站編輯    發布日期：2021-03-10

專利號 EP17886906.1

專利名稱

Preparation method for implantable medical biological materials of animal origin

一種動物源性植入性醫用生物材料的制備方法

發明人

趙博 王振軍

摘要

The present invention provides a preparation method for implantable medical biological material of animal origin comprising the following procedures: Pre-processing, and washing of animal tissue materials; inactivation of virus; decellularizing cell; sodium chloride processing; molding and packaging sterilization. Cell-free ECM materials of animal origin produced by this method can achieve the goal of completely removing cell components of animal origin and composition of DNA, and at the same time, the natural ECM composition, three-dimensional structure and active growth factor which can induce and promote tissue regeneration retain. By using this process, endotoxin, organic solvents and toxic solvent residue are thus omitted and products with different sizes, thickness and mechanical strength can be formed.

一種動物源性植入性醫用生物材料的制備方法，它包括以下操作步驟：動物組織材料的前置處理與初洗；病毒滅活；脫細胞；氯化鈉處理；成型；包裝滅菌。用該方法制備的動物源性脫細胞ECM材料完全去除了動物源細胞成分和DNA成分，同時完整的保留了天然ECM的成分、三維結構和能夠誘導促進組織再生的活性生長因子，無內毒素、有機溶劑和有毒溶劑殘留，并可根據不同的適應癥形成具有不同尺寸、厚度和力學強度的產品。